Automated Signal Processing

automated signal processing

Software for analysis of nematode behaviour.

 

Tracking software

Nematodes display a number of different, simple behaviours, which can be easily quantified. We have tools that permit the automated analysis of locomotory patterns and the identification and quantification of distinct behavioural states.

Read article.

C. elegans behavioural states are heavily dependent upon food, in terms of both its abundance and quality. We have utilised this behavioural phenomenon as a basis to develop a protocol for conducting toxicological screening.

automated signal processing

EPG software 

Feeding behaviour of C. elegans is regulated by a neural system which controls the rhythmic contraction and relaxation of the pharyngeal muscle. The activity of this neuromuscular network, called an electropharyngeaogram or EPG, can be recorded using a microfluidic device, NeuroChip. AutoEPG software was designed in collaboration with EMBody-biosignals  and enables analysis of the EPG  signal. It identifies and annotates discrete features of the EPG waveform that provide a readout of effects on a range of potential chemical or drug targets encompassing neurotransmitter receptors,  ion channels and intracellular enzymes.

AutoEPG provides an excellent ‘first-pass’ for the identification and prioritisation of neurologically relevant and novel chemical entities.

epg-annotation1
Neurotransmitter / channel
Pharyngeal phenotype
Serotonin Δ frequency
Acetylcholine Δ ‘e’ and frequency
BK potassium Δ pattern (bursting)
Glutamate Δ ‘p’
annotated epg