Automated Signal Processing

automated signal processing

Software for analysis of nematode behaviour.


Tracking software

Nematodes display a number of different, simple behaviours, which can be easily quantified. We have tools that permit the automated analysis of locomotory patterns and the identification and quantification of distinct behavioural states.

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C. elegans behavioural states are heavily dependent upon food, in terms of both its abundance and quality. We have utilised this behavioural phenomenon as a basis to develop a protocol for conducting toxicological screening.

automated signal processing

EPG software 

Feeding behaviour of C. elegans is regulated by a neural system which controls the rhythmic contraction and relaxation of the pharyngeal muscle. The activity of this neuromuscular network, called an electropharyngeaogram or EPG, can be recorded using a microfluidic device, NeuroChip. AutoEPG software was designed in collaboration with EMBody-biosignals  and enables analysis of the EPG  signal. It identifies and annotates discrete features of the EPG waveform that provide a readout of effects on a range of potential chemical or drug targets encompassing neurotransmitter receptors,  ion channels and intracellular enzymes.

AutoEPG provides an excellent ‘first-pass’ for the identification and prioritisation of neurologically relevant and novel chemical entities.

Neurotransmitter / channel
Pharyngeal phenotype
Serotonin Δ frequency
Acetylcholine Δ ‘e’ and frequency
BK potassium Δ pattern (bursting)
Glutamate Δ ‘p’
annotated epg