Key Publications

Crisford A, Calahorro F, Ludlow E, Marvin JMC, Hibbard JK, Lilley CJ, Kearn J, Keefe F, Johnson P, Harmer R, Urwin PE, O’Connor V, Holden-Dye L. Identification and characterisation of serotonin signalling in the potato cyst nematode Globodera pallida reveals new targets for crop protection. PLoS Pathog. 2020 Oct 2;16(10):e1008884. doi: 10.1371/journal.ppat.1008884. PMID: 33007049; PMCID: PMC7556481.

Feist E, Kearn J, Gaihre Y, O’Connor V, Holden-Dye L. The distinct profiles of the inhibitory effects of fluensulfone, abamectin, aldicarb and fluopyram on Globodera pallida hatching. Pestic Biochem Physiol. 2020 May;165:104541. doi: 10.1016/j.pestbp.2020.02.007. Epub 2020 Feb 5. PMID: 32359561.

Scott E, Holden-Dye L, O’Connor V, Wand ME. Intra Strain Variation of the Effects of Gram-Negative ESKAPE Pathogens on Intestinal Colonization, Host Viability, and Host Response in the Model Organism Caenorhabditis elegans. Front Microbiol. 2020 Jan 21;10:3113. doi: 10.3389/fmicb.2019.03113. PMID: 32038555; PMCID: PMC6985274.

Mulcahy B, Ibbett P, Holden-Dye L, O’Connor V. The Caenorhabditis elegans cysteine-string protein homologue DNJ-14 is dispensable for neuromuscular junction maintenance across ageing. J Exp Biol. 2019 Nov 25;222(Pt 22):jeb205450. doi: 10.1242/jeb.205450. PMID: 31624097.

Calahorro F, Keefe F, Dillon J, Holden-Dye L, O’Connor V. Neuroligin tuning of pharyngeal pumping reveals extrapharyngeal modulation of feeding in Caenorhabditis elegans. J Exp Biol. 2019 Feb 8;222(Pt 3):jeb189423. doi: 10.1242/jeb.189423. PMID: 30559302.

Holden-Dye L, Walker RJ. Invertebrate models of behavioural plasticity and human disease. Brain Neurosci Adv. 2018 Dec 7;2:2398212818818068. doi: 10.1177/2398212818818068. PMID: 32166171; PMCID: PMC7058240.

Dillon J, Holden-Dye L, O’Connor V. Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans. Invert Neurosci. 2018 Nov 11;18(4):16. doi: 10.1007/s10158-018-0218-2. PMID: 30417267.

Blanchard A, Guégnard F, Charvet CL, Crisford A, Courtot E, Sauvé C, Harmache A, Duguet T, O’Connor V, Castagnone-Sereno P, Reaves B, Wolstenholme AJ, Beech RN, Holden-Dye L, Neveu C. Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species. PLoS Pathog. 2018 May 2;14(5):e1006996. doi: 10.1371/journal.ppat.1006996. PMID: 29719008; PMCID: PMC5931475.

Jékely G, Melzer S, Beets I, Kadow ICG, Koene J, Haddad S, Holden-Dye L. The long and the short of it – a perspective on peptidergic regulation of circuits and behaviour. J Exp Biol. 2018 Feb 8;221(Pt 3):jeb166710. doi: 10.1242/jeb.166710. PMID: 29439060.

Kearn J, Lilley C, Urwin P, O’Connor V, Holden-Dye L. Progressive metabolic impairment underlies the novel nematicidal action of fluensulfone on the potato cyst nematode Globodera pallida. Pestic Biochem Physiol. 2017 Oct;142:83-90. doi: 10.1016/j.pestbp.2017.01.009. Epub 2017 Jan 13. PMID: 29107251..

Scott E, Hudson A, Feist E, Calahorro F, Dillon J, de Freitas R, Wand M, Schoofs L, O’Connor V, Holden-Dye L. An oxytocin-dependent social interaction between larvae and adult C. elegans. Sci Rep. 2017 Aug 31;7(1):10122. doi: 10.1038/s41598-017-09350-7. PMID: 28860630; PMCID: PMC5579267.

Smus JP, Ludlow E, Dallière N, Luedtke S, Monfort T, Lilley C, Urwin P, Walker RJ, O’Connor V, Holden-Dye L, Mahajan S. Coherent anti-Stokes Raman scattering (CARS) spectroscopy in Caenorhabditis elegans and Globodera pallida: evidence for an ivermectin-activated decrease in lipid stores. Pest Manag Sci. 2017 Dec;73(12):2550-2558. doi: 10.1002/ps.4707. Epub 2017 Sep 25. PMID: 28834172; PMCID: PMC5698734..

Kudelska MM, Holden-Dye L, O’Connor V, Doyle DA. Concentration-dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans. Pest Manag Sci. 2017 Jul;73(7):1345-1351. doi: 10.1002/ps.4564. Epub 2017 May 9. PMID: 28261957.

Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ. Chemical activation of a food deprivation signal extends lifespan. Aging Cell. 2016 Oct;15(5):832-41. doi: 10.1111/acel.12492. Epub 2016 May 24. PMID: 27220516; PMCID: PMC5013014.

Dillon J, Holden-Dye L, O’Connor V, Hopper NA. Context-dependent regulation of feeding behaviour by the insulin receptor, DAF-2, in Caenorhabditis elegans. Invert Neurosci. 2016 Jun;16(2):4. doi: 10.1007/s10158-016-0187-2. Epub 2016 May 21. PMID: 27209024; PMCID: PMC4875951.

Courtot E, Charvet CL, Beech RN, Harmache A, Wolstenholme AJ, Holden-Dye L, O’Connor V, Peineau N, Woods DJ, Neveu C. (2015) Functional Characterization of a novel class of morantel-sensitive acetylcholine receptors in nematodes.PLoS Pathog. 11(12):e1005267

Crisford A, Ebbinghaus-Kintscher U, Schoenhense E, Harder A, Raming K, O’Kelly I, Ndukwe K, O’Connor V, Walker RJ, Holden-Dye L. (2015) The cyclooctadepsidpeptide anthelmintic emodepside differentially modulates nematode, insect and human calcium-activated potassium (SLO) channel alpha subunits.  PLOS Negl Trop Dis 10.1371; 0004062.

Holden-Dye L, Walker RJ. (2014)  Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans. WormBook. Dec 16:1-29. doi: 10.1895 

Guest M, Bull K, Walker RJ, Amliwala K, O’Connor V, Harder A, Holden-Dye L, Hopper NA. (2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol. 37(14):1577-88.

Kearn J, Ludlow E, Dillon J, O’Connor V, Holden-Dye L. (2014) Fluensulfone is a nematicide with a mode of action distinct from anticholinesterases and macrocyclic lactones. Pestic Biochem Physiol. 109:44-57.

Hu C, Dillon J, Kearn J, Murray C, O’Connor V, Holden-Dye L, Morgan H. (2013) NeuroChip: a microfluidic electrophysiological device for genetic and chemical biology screening of Caenorhabditis elegans adult and larvae. PLoS One. 8(5):e64297.

Perney NM, Braddick L, Jurna M, Garbacik ET, Offerhaus HL, Serpell LC, Blanch E, Holden-Dye L, Brocklesby WS, Melvin T. (2012) Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy. PLoS One. 7(7):e40536.

Dillon J, Andrianakis I, Bull K, Glautier S, O’Connor V, Holden-Dye L, James C. (2009) AutoEPG: software for the analysis of electrical activity in the microcircuit underpinning feeding behaviour of Caenorhabditis elegans. PLoS One. 4(12):e8482.

Hu C, Kearn J, Urwin P, Lilley C, O’ Connor V, Holden-Dye L, Morgan H. (2014) StyletChip: a microfluidic device for recording host invasion behaviour and feeding of plant parasitic nematodes. Lab Chip. 14(14):2447-55

Dillon J, Franks CJ, Murray C, Edwards RJ, Calahorro F, Ishihara T, Katsura I, Holden-Dye L, O’Connor V. (2015) Metabotropic Glutamate Receptors: Modulators of context-dependent feeding behaviours in C. elegans J. Biol Chem.290(24):15052-65.

Calahorro F, Holden-Dye L, O’Connor V. (2015) Analysis of splice variants for the C. elegans orthologue of human neuroligin reveals a developmentally regulated transcript. Gene Expr Patterns. 17:69-78.

Dillon J, Andrianakis I, Mould R, Ient B, Liu W, James C, O’Connor V, Holden-Dye L. (2013) Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans. FASEB J. 27(10):4266-78.

Holden-Dye L, Joyner M, O’Connor V, Walker RJ.Nicotinic acetylcholine receptors: a comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes. (2013) Parasitol Int. 62(6):606-15.

Holden-Dye L, Walker RJ. (2011) Neurobiology of plant parasitic nematodes. Invert Neurosci. 11(1):9-19.

Welz C, Krüger N, Schniederjans M, Miltsch SM, Krücken J, Guest M, Holden-Dye L, Harder A, von Samson-Himmelstjerna G. (2011)  SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. PLoS Pathog. 7(4):e1001330.

Crisford A, Murray C, O’Connor V, Edwards RJ, Kruger N, Welz C, von Samson-Himmelstjerna G, Harder A, Walker RJ, Holden-Dye L. (2011) Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in Caenorhabditis elegans. Mol Pharmacol. 79(6):1031-43.

Mulcahy B, Holden-Dye L, O’Connor V. (2013) Pharmacological assays reveal age-related changes in synaptic transmission at the Caenorhabditis elegans neuromuscular junction that are modified by reduced insulin signalling. J Exp Biol. 216(3):492-501.

Guest M, Bull K, Walker RJ, Amliwala K, O’Connor V, Harder A, Holden-Dye L, Hopper NA. (2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol. 37(14):1577-88.