Key Publications

Courtot E, Charvet CL, Beech RN, Harmache A, Wolstenholme AJ, Holden-Dye L, O’Connor V, Peineau N, Woods DJ, Neveu C. (2015) Functional Characterization of a novel class of morantel-sensitive acetylcholine receptors in nematodes.PLoS Pathog. 11(12):e1005267

Crisford A, Ebbinghaus-Kintscher U, Schoenhense E, Harder A, Raming K, O’Kelly I, Ndukwe K, O’Connor V, Walker RJ, Holden-Dye L. (2015) The cyclooctadepsidpeptide anthelmintic emodepside differentially modulates nematode, insect and human calcium-activated potassium (SLO) channel alpha subunits.  PLOS Negl Trop Dis 10.1371; 0004062.

Holden-Dye L, Walker RJ. (2014)  Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans. WormBook. Dec 16:1-29. doi: 10.1895 

Guest M, Bull K, Walker RJ, Amliwala K, O’Connor V, Harder A, Holden-Dye L, Hopper NA. (2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol. 37(14):1577-88.

Kearn J, Ludlow E, Dillon J, O’Connor V, Holden-Dye L. (2014) Fluensulfone is a nematicide with a mode of action distinct from anticholinesterases and macrocyclic lactones. Pestic Biochem Physiol. 109:44-57.

Hu C, Dillon J, Kearn J, Murray C, O’Connor V, Holden-Dye L, Morgan H. (2013) NeuroChip: a microfluidic electrophysiological device for genetic and chemical biology screening of Caenorhabditis elegans adult and larvae. PLoS One. 8(5):e64297.

Perney NM, Braddick L, Jurna M, Garbacik ET, Offerhaus HL, Serpell LC, Blanch E, Holden-Dye L, Brocklesby WS, Melvin T. (2012) Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy. PLoS One. 7(7):e40536.

Dillon J, Andrianakis I, Bull K, Glautier S, O’Connor V, Holden-Dye L, James C. (2009) AutoEPG: software for the analysis of electrical activity in the microcircuit underpinning feeding behaviour of Caenorhabditis elegans. PLoS One. 4(12):e8482.

Hu C, Kearn J, Urwin P, Lilley C, O’ Connor V, Holden-Dye L, Morgan H. (2014) StyletChip: a microfluidic device for recording host invasion behaviour and feeding of plant parasitic nematodes. Lab Chip. 14(14):2447-55

Dillon J, Franks CJ, Murray C, Edwards RJ, Calahorro F, Ishihara T, Katsura I, Holden-Dye L, O’Connor V. (2015) Metabotropic Glutamate Receptors: Modulators of context-dependent feeding behaviours in C. elegans J. Biol Chem.290(24):15052-65.

Calahorro F, Holden-Dye L, O’Connor V. (2015) Analysis of splice variants for the C. elegans orthologue of human neuroligin reveals a developmentally regulated transcript. Gene Expr Patterns. 17:69-78.

Dillon J, Andrianakis I, Mould R, Ient B, Liu W, James C, O’Connor V, Holden-Dye L. (2013) Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans. FASEB J. 27(10):4266-78.

Holden-Dye L, Joyner M, O’Connor V, Walker RJ.Nicotinic acetylcholine receptors: a comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes. (2013) Parasitol Int. 62(6):606-15.

Holden-Dye L, Walker RJ. (2011) Neurobiology of plant parasitic nematodes. Invert Neurosci. 11(1):9-19.

Welz C, Krüger N, Schniederjans M, Miltsch SM, Krücken J, Guest M, Holden-Dye L, Harder A, von Samson-Himmelstjerna G. (2011)  SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. PLoS Pathog. 7(4):e1001330.

Crisford A, Murray C, O’Connor V, Edwards RJ, Kruger N, Welz C, von Samson-Himmelstjerna G, Harder A, Walker RJ, Holden-Dye L. (2011) Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in Caenorhabditis elegans. Mol Pharmacol. 79(6):1031-43.

Mulcahy B, Holden-Dye L, O’Connor V. (2013) Pharmacological assays reveal age-related changes in synaptic transmission at the Caenorhabditis elegans neuromuscular junction that are modified by reduced insulin signalling. J Exp Biol. 216(3):492-501.

Guest M, Bull K, Walker RJ, Amliwala K, O’Connor V, Harder A, Holden-Dye L, Hopper NA. (2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol. 37(14):1577-88.